Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle
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چکیده
منابع مشابه
Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle.
Disruptions in the use of skeletal muscle lead to muscle atrophy. After short periods of disuse, muscle atrophy is reversible, and even after prolonged periods of inactivity, myofiber degeneration is uncommon. The pathways that regulate atrophy, initiated either by peripheral nerve damage, immobilization, aging, catabolic steroids, or cancer cachexia, however, are poorly understood. Previously,...
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Recent human genetic studies have provided evidences that sporadic or inherited missense mutations in four-and-a-half LIM domain protein 1 (FHL1), resulting in alterations in FHL1 protein expression, are associated with rare congenital myopathies, including reducing body myopathy and Emery-Dreifuss muscular dystrophy. However, it remains to be clarified whether mutations in FHL1 cause skeletal ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2005
ISSN: 0890-9369
DOI: 10.1101/gad.1318305